Ketamine has gained widespread attention for its ability to treat mental health conditions, especially treatment-resistant depression (TRD). At Axis Integrated Mental Health in Denver, we use ketamine therapy and Spravato to help patients who haven’t found relief through traditional options finally feel better. This article is designed to dispel the myths and educate readers about how ketamine works and why it might be the right solution for you or your loved ones.
Originally developed as an anesthetic in the 1960s, ketamine helps decrease pain and memory during surgery. But in the 1990s, researchers discovered that at lower doses, ketamine can relieve depressive symptoms in patients almost immediately. Today, about 70% of depression patients who receive ketamine therapy report significant relief, often within hours or days. Compare that to traditional antidepressants, which may take weeks and only help 40–60% of users.
Ketamine works differently from SSRIs or SNRIs. Instead of targeting serotonin, ketamine promotes neuroplasticity—essentially helping the brain "rewire" and create new, healthier connections. This is particularly effective for those who’ve tried multiple medications without success. For many patients, ketamine is the breakthrough that helps them move forward.
You may have heard ketamine referred to as a "horse tranquilizer" or feared its reputation as a party drug. While these associations are based on real uses, they do not reflect how ketamine is used in a medical setting. When administered by trained professionals in a clinical environment, ketamine is safe, effective, and life-changing.
Receiving ketamine in a professional mental health clinic is crucial. Dosage must be carefully calculated—too little may not help, and too much can worsen symptoms. Moreover, street ketamine may be laced with dangerous substances like fentanyl. At Axis, treatments are overseen by licensed professionals in a calm, therapeutic environment, maximizing benefits and minimizing risks.
Spravato (esketamine) is a nasal spray version of ketamine that is FDA-approved for treating depression. It must be administered in a certified clinic and is covered by many insurance plans. Spravato offers a structured, evidence-based option for those seeking help with treatment-resistant depression.
Unlike traditional ketamine infusions, Spravato is often covered by insurance. At Axis Integrated Mental Health, we work with most insurance providers to reduce the out-of-pocket cost for our patients. We also provide detailed resources to help you understand the costs and what’s covered.
Many of our patients have seen dramatic improvement through ketamine therapy—from regaining interest in life to finding hope where there was once only despair. Their journeys mirror what recent studies have shown: ketamine can truly change lives.
In a recent Washington Post article, patients described transformations after just a few ketamine treatments. One man who had spent 15 years unable to leave his bed found himself singing to his dogs and going for walks. A retired hospital technician found the confidence to look people in the eyes. Another patient said, “I don’t know that I’d be here” without ketamine therapy. These stories are not just anecdotes—they are reflections of real-world outcomes supported by clinical research, with 72% of patients in a study experiencing significant mood improvements and 38% becoming symptom-free after 10 treatments.
Axis offers a holistic approach that goes beyond medication. We combine ketamine therapy with talk therapy, nutritional psychiatry, and other evidence-based practices. Our team is passionate about helping patients achieve sustainable mental wellness.
What makes Axis different is our integrated care model. We don’t just offer ketamine—we use it as part of a broader healing plan. Whether it’s TMS, lifestyle changes, or ongoing psychotherapy, we help our patients find lasting relief.
If you suffer from treatment-resistant depression, anxiety, PTSD, OCD, or suicidal thoughts and haven’t found relief with other treatments, ketamine therapy may be your next step. Contact Axis Integrated Mental Health at (720) 400-7025 or schedule a consultation today to take control of your mental health.