If you’ve struggled with depression that hasn’t responded to other treatments, you might be wondering: How do I find Spravato treatment near me? In this guide, we’ll walk you through everything you need to know—from how Spravato works to what to expect during treatment, how to find a certified center, and how to make it affordable.

What Is Spravato? A Breakthrough for Treatment-Resistant Depression

If you've struggled with depression that hasn't responded to other treatments, you're not alone. You might be wondering, "How do I find Spravato treatment near me?"

This guide will walk you through what Spravato is, what to expect during treatment, and what makes Axis Integrated Mental Health a leading choice for Spravato in Denver, Boulder, and Westminster.

What Is Spravato? A Breakthrough for Treatment-Resistant Depression

Spravato® (esketamine) (esketamine) is the only FDA-approved nasal spray for adults with treatment-resistant depression (TRD). Unlike traditional antidepressants (SSRIs), which can take weeks to work, Spravato targets the brain's NMDA receptors to rapidly boost neuroplasticity—the brain’s ability to form new connections—providing faster relief.

Spravato is also approved for adults with major depressive disorder (MDD) who have suicidal thoughts.

What Makes Axis Integrated Mental Health Different?

At Axis, we believe healing happens when people feel seen, understood, and supported. We provide more than just medication; we offer a personalized, holistic approach to your mental health journey.

• Integrated Care: Your Spravato journey is part of a larger plan that includes psychiatric support, therapy, and trauma-informed care—all under one roof. We treat you as a whole person, not just a set of symptoms.

• Insurance Advocates: Navigating insurance can be a headache. Our team handles prior authorizations, benefits checks, and appeals for you so you can focus on your healing. Most major insurance plans cover Spravato, and we make sure you get the most from your benefits.

• Comfortable, Private Treatment Suites: No sterile hospital rooms here. Our cozy, low-stimulation Spravato rooms feature zero-gravity chairs, blankets, music, and noise-canceling headphones, providing a safe and peaceful environment for recovery.

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• Transportation Support: To ensure you never miss a session, all new patients receive a complimentary Uber voucher to and from treatment.

• A Community-Focused Clinic: We are a Colorado-grown, award-winning clinic deeply invested in our local communities across Denver, Boulder, and Westminster. You’re not just a patient; you’re part of the support system you live in.

Unlike SSRIs, Spravato doesn't simply increase neurotransmitter levels. Instead, it targets the NMDA receptor and boosts neuroplasticity–your brain’s ability to form new connections–helping you feel relief faster. Research shows that it begins enhancing these connections within just hours of administration.

Understanding Your Spravato Treatment Journey

What to Expect During a Session: During your two-hour visit at our clinic, you will self-administer the Spravato nasal spray under the close supervision of our clinical team. Your vitals will be monitored throughout the session to ensure your safety and comfort.

Typical Treatment Schedule:

• Weeks 1–4: Twice per week

• Weeks 5–8: Once per week

• After Week 8: Maintenance varies, typically once every 2 to 4 weeks, based on your response.

Common Side Effects of Ketamine Therapy:

• Dissociation (feeling disconnected)

• Nausea or vomiting

• Drowsiness or fatigue

• Increased blood pressure

• Headache or dizziness

To manage these, we offer anti-nausea medication and ensure a safe, supportive environment. You will need to arrange a ride home post-treatment due to temporary sedation.

Spravato for Anxiety: What the Research Shows

Although Spravato is not yet FDA-approved specifically for anxiety, studies show it can improve symptoms of co-occurring anxiety in patients with depression. Social functioning, ability to work, and quality of life often improve.

Spravato vs Traditional Ketamine: Why FDA Approval Matters

While Spravato and ketamine are both used to treat depression, they’re not the same. Ketamine is a decades-old anesthetic that’s used off-label in low doses for depression, typically administered through an IV. Spravato®, on the other hand, is a prescription nasal spray version of esketamine–a close chemical cousin of ketamine. Unlike ketamine, Spravato is FDA-approved specifically for treatment-resistant depression and must be administered in a certified clinic like Axis under direct supervision, and it’s covered by most insurance plans, unlike IV ketamine. We provide greater detail about the differences between Spravato vs Ketamine on our blog. 

How to Find a Spravato Treatment Clinic Near You

Use the official Spravato Treatment Center Locator to find certified clinics by ZIP code. Most do not require a referral, but consult your primary provider for input.

Understanding the Cost of Spravato Treatment and How to Save

Factors That Affect Cost:

• Frequency of sessions
• Insurance copays
• Provider fees

How to Reduce Costs:

• Insurance: Most major plans cover Spravato
• Spravato withMe Savings Card: May reduce cost to $10/visit for eligible patients
• Patient Assistance Programs: Support is available for those who qualify

We handle the enrollment process for you.

Read more on Spravato cost here.

Still Wondering Where to Go for Spravato? Let Us Help

Axis Integrated Mental Health offers personalized consultations to help you choose the best path forward. Call us at (720) 400-7025 or book an appointment online to start your journey toward better mental health.

People Also Ask

How do I know if I'm a good candidate for Spravato treatment?

Spravato is primarily for adults with treatment-resistant depression (TRD), which means you haven't found success with at least two other oral antidepressants. It is also approved for adults with major depressive disorder (MDD) who have acute suicidal ideation or behavior. A psychiatric provider will conduct a thorough evaluation of your medical and mental health history to determine if you meet the specific criteria for treatment.

Will my insurance cover the cost of Spravato sessions?

In most cases, yes. Spravato is the only FDA-approved esketamine nasal spray specifically for depression, which means most major insurance plans will cover it. Our team will handle the benefits check and prior authorization process to ensure you get the maximum coverage.

What's the difference between Spravato and regular ketamine infusions?

Spravato and traditional ketamine infusions are both used for depression, but they are not the same. Spravato is a nasal spray version of esketamine that is FDA-approved specifically for TRD, making it widely covered by insurance. Regular ketamine is an anesthetic that is used "off-label" for depression, typically administered via an IV. It's not FDA-approved for depression and is therefore less likely to be covered by insurance.

Can I continue my job or daily routine while receiving Spravato?

You can continue your daily routine, but with some modifications. After a Spravato session, you will be monitored for two hours and must arrange for a ride home due to temporary sedation and side effects like dizziness. Therefore, you can't drive yourself and should avoid operating heavy machinery or making important decisions for the rest of the day.

Is a referral needed to begin Spravato treatment at Axis?

No, a referral is not required to begin Spravato treatment at our clinic. You can schedule a consultation directly with us to start your evaluation. However, we always recommend consulting with your primary care provider as part of a comprehensive health plan.