Depression Treatment in Denver: Traditional & Alternative Options That Work

What Is the Best Depression Treatment in Denver?

If you're struggling with depression in Denver, you're not alone—and you're not without options. At Axis Integrated Mental Health, we understand that no two cases of depression are the same. Whether you've tried standard antidepressants without success or you're looking for something that works faster, we offer personalized care that includes both traditional and alternative treatments to help you reclaim your life.

Traditional Depression Treatments: How They Work & Where They Fall Short

Selective serotonin reuptake inhibitors (SSRIs) are often the first-line treatment for depression. These medications increase serotonin levels in the brain to improve mood. While they work for many, they often take weeks to show results and can come with side effects like weight gain, fatigue, sexual dysfunction, and gastrointestinal issues.

In many cases, SSRIs are combined with mood stabilizers, antipsychotics, or psychotherapy. For patients who respond well, this can be enough. But for those with treatment-resistant depression, it's time to look beyond SSRIs.

Why More People Are Turning to Alternative Depression Treatments

If you've tried multiple antidepressants with little relief, you're not alone. Up to 60% of people with depression experience limited or no improvement with traditional medications. That’s where alternative treatments like ketamine, Spravato, and transcranial magnetic stimulation (TMS) come in.

Ketamine Infusion Therapy: Fast Relief When You Need It Most

Ketamine works differently from SSRIs. By targeting NMDA receptors and boosting glutamate in the brain, it creates new neural connections and often provides rapid relief, sometimes within hours.

At Axis, IV ketamine infusions are administered in a controlled, professional setting. A series of 6–8 treatments is typically recommended. Costs range from $450–$800 per infusion and are not covered by insurance. Side effects can include nausea, dissociation, and temporary changes in blood pressure.

Spravato (Esketamine): Insurance-Friendly and Effective

Spravato is a nasal spray version of esketamine that offers similar benefits to ketamine infusions. It's FDA-approved for treatment-resistant depression and typically covered by insurance, sometimes costing as little as $10 per visit for eligible patients.

Spravato treatments occur under supervision in our clinic and last about two hours. Side effects are similar to ketamine infusions, including nausea and temporary dissociation.

TMS for Depression: A Non-Invasive, Covered Treatment

TMS uses magnetic fields to stimulate areas of the brain involved in mood regulation. It doesn’t require medication or sedation, and sessions are short—around 30 minutes. TMS is covered by most insurance plans and typically costs $300–$500 per session.

While TMS takes several weeks to work, it has virtually no systemic side effects, making it an excellent option for people seeking a non-pharmacological treatment.

Integrative Psychiatry: We Treat the Whole Person

At Axis, we believe mental health is more than just medication. Our holistic approach includes psychotherapy, cognitive-behavioral therapy (CBT), and lifestyle coaching.

We help our patients develop sustainable habits like exercise, journaling, mindfulness, and improved nutrition—all of which play a vital role in managing depression.

What Makes Axis Different: Inclusive, Empathetic Mental Health Care

As one of Denver’s few BIPOC-owned and operated psychiatric clinics, Axis Integrated Mental Health offers culturally responsive, empathetic care. We meet patients where they are—whether they’re just starting treatment or looking for new options after years of struggle.

Medication Isn't Magic—It's One Piece of the Puzzle

Too often, people view medication as a "cure" for depression. At Axis, we see it as one tool in a comprehensive, long-term strategy. We coach you in behavioral change, self-awareness, and resilience—so that even after the treatment ends, your progress doesn’t.

Get Personalized Depression Treatment in Denver Today

If you're ready to explore traditional and alternative treatment options for depression in Denver, we’re here to help. Book a telehealth intake or call us at (720) 400-7025 to schedule an in-person visit.