Is Ketamine Infusion Therapy the Answer to Your Treatment-Resistant Depression?

Is Ketamine Infusion Therapy the Answer to Your Treatment-Resistant Depression?

Depression is hard. But when you’ve tried multiple antidepressants with no relief, it becomes a different kind of struggle. This is called treatment-resistant depression (TRD), and for many people, it can feel like there’s no way out.

At Axis Integrated Mental Health, we understand that pain. That’s why we offer cutting-edge solutions like ketamine infusion therapy—a safe, medically supervised treatment shown to rapidly relieve even the most stubborn depression.

What Is Ketamine Infusion Therapy?

Ketamine was originally developed as an anesthetic in the 1960s and later used in combat medicine. Today, it’s making headlines as one of the most promising treatments for depression, particularly when traditional medications fail. Administered in small doses via IV in a clinical setting, ketamine therapy offers fast-acting relief and helps the brain recover from the effects of long-term depression.

How Does Ketamine Work in the Brain?

Unlike standard antidepressants that target serotonin, ketamine blocks NMDA receptors and regulates the brain’s glutamate system. This action triggers a rapid increase in Brain-Derived Neurotrophic Factor (BDNF) and enhances neuroplasticity—allowing the brain to regrow lost synapses and repair communication between neural networks.

These changes help "reset" the brain’s Default Mode Network, which is often overactive in people with depression. Studies show that within 24 hours of a ketamine infusion, patients may start forming new brain connections—offering both immediate and lasting symptom relief.

What to Expect During Your Ketamine Treatment at Axis

Your comfort and safety are our top priorities. Here’s what a typical infusion looks like at Axis:

• You’ll be guided to one of our relaxing, spa-like treatment rooms.

• We offer spa socks, soothing scents, foot balm, and your choice of music.

• A trained provider places a small IV in your hand or arm.

• The infusion lasts 40 minutes to 2 hours, with continuous monitoring.

• Afterward, we provide snacks and beverages as you gently return to normal.

• You’ll need a ride home and should plan to rest for 24 hours.

How Quickly Will You Feel Relief?

Patients often experience some symptom relief after the first session, with more profound changes by the 3rd or 4th infusion. A full course typically includes 6 infusions over 2 to 3 weeks. At Axis, we personalize every treatment plan—and we even offer weekend infusions to accommodate your schedule.

How Ketamine Compares to Antidepressants

• Faster onset: Ketamine can begin relieving symptoms within hours.

• Helps when others fail: Ideal for patients who haven’t responded to at least two antidepressants.

• Effective for suicidality: Offers immediate support in crisis situations.

• Shorter treatment timeline: Most courses finish in weeks, not months.

Ketamine Safety, Side Effects, and Who Should Avoid It

Ketamine is extremely safe when administered by trained professionals. At Axis, all providers are board-certified and experienced in hospital-level care.

Common short-term side effects include:

• Dissociation or "floaty" sensations

• Elevated blood pressure or heart rate

• Nausea or blurry vision

• Heightened sensitivity to sound or color

These effects fade shortly after the infusion. We recommend avoiding negative media and opting for relaxing activities beforehand.

Ketamine is not appropriate for individuals with:

• Active psychosis or schizophrenia

• Uncontrolled hypertension or heart disease

• Severe substance use disorders

• Pregnancy

How Much Does Ketamine Treatment Cost?

Although ketamine infusion therapy is not typically covered by insurance, Axis Integrated Mental Health works to make treatment affordable. We offer low-interest payment plans and assist with third-party medical financing.

IV vs. Nasal Spray: What’s the Difference?

IV ketamine has the strongest evidence for effectiveness and is the method we use at Axis. Nasal spray options like Spravato are available elsewhere but may not deliver the same rapid or sustained results. Our providers can help you decide what’s right for you.

Why Choose Axis for Ketamine in Denver?

• Local, compassionate care in Denver and Aurora

• Weekend appointments to fit your schedule

• Spa-like experience tailored for healing

• Experienced medical professionals

• Personalized infusion plans based on your needs

More Resources and Next Steps

Photo by Anthony Tran on Unsplash

Depression is a complex issue, and you or your loved one deserves someone who cares about you and your symptoms as much as you do. There is no reason to suffer from depression when there is a viable treatment option available.

We hope this article has helped you understand the benefits of using Ketamine to treat depression. We also want you to know that if you’re still suffering from depression, we can help. 

Learn more or book your consultation today:

• FAQs about Ketamine Treatment

• To schedule a consultation with one of our providers, please reach out to us at (720) 400-7025 or book online.