Post COVID Depression: 14 Symptoms to Know and 5 Proven Recovery Strategies in Denver

Is Post-COVID Depression Real? (And Why It’s More Common Than You Think)

Post-COVID depression is very real. For many, the emotional effects of the pandemic persist long after the virus itself is gone. Depression symptoms can appear as early as 2-3 months after infection, and for some, they have never resolved.

14 Post-COVID Depression Symptoms to Watch For

If you or someone you love is experiencing the following symptoms, it may be more than just a rough patch:

1. Lack of interest in hobbies, relationships, or sex

2. Difficulty completing basic tasks (like getting out of bed)

3. Irritability, frustration, or emotional outbursts

4. Persistent sadness, emptiness, or hopelessness

5. Insomnia or excessive sleep

6. Fatigue or lack of energy

7. Appetite changes or weight fluctuations

8. Anxiety or restlessness

9. Slowed thoughts, speech, or movement

10. Feelings of worthlessness or guilt

11. Trouble concentrating or remembering things

12. Suicidal thoughts or ideation

13. Unexplained aches and pains

14. Mental health medications that suddenly stop working

Why Post-COVID Depression Happens: The Science Behind the Symptoms

No two cases are alike, but many root causes are shared. Research shows several biological and psychological mechanisms may be at play:

• Immune-inflammatory response: COVID-19 can trigger an inflammatory state that impacts brain chemistry and mood regulation.

• Gut-brain disruption: COVID alters gut microbiota, which can affect serotonin and dopamine production, contributing to mood disorders.

• Psychological stress: Isolation, fear, economic instability, and health anxiety also increase the risk of depression.

COVID Long Haulers and Mood Disorders: What the Research Shows

People who experienced severe symptoms, were hospitalized, or faced prolonged recovery are at higher risk. In fact, depression may last up to a year or more after infection. Early intervention is crucial.

COVID or Just the Blues? How to Tell the Difference

Typical stress or sadness improves with time. But when low mood lingers beyond two weeks, interferes with daily life, or includes hopelessness or suicidal thoughts, it may be post-COVID depression.

5 Proven Ways to Recover From Post-COVID Depression

1. Talk to a professional. Whether it's a therapist or psychiatric provider, Axis makes care easy with no referral required and accepts most insurance.

2. Eat for your brain. Nutritional psychiatry is showing that what you eat affects your mood. Omega-3s, probiotics, and vitamins can support recovery.

3. Get outside and move. A simple walk can activate the brain's relaxation system and release endorphins.

4. Try meditation. Guided meditations, apps, and breathing exercises can lower stress hormones.

5. Prioritize sleep. Good sleep heals the brain and regulates gut health, both critical for mental health.

When Antidepressants Stop Working After COVID

It’s not uncommon for previously effective medications to stop working after COVID. Inflammation and brain chemistry shifts may require reassessment and possibly a new treatment approach.

Effective Alternative Treatments: TMS, Ketamine & Spravato

• TMS (Transcranial Magnetic Stimulation) has been shown to improve depression and brain fog in long COVID patients.

• Ketamine & Spravato have both anti-inflammatory and rapid-acting antidepressant effects, making them promising options for post-COVID depression.

Treatments We Don't Recommend: Marijuana & Psilocybin

• Marijuana may worsen anxiety and motivation issues.

• Psilocybin, though being studied, lacks consistent dosing and safety protocols and is not currently a recommended treatment at Axis.

How Axis Integrated Mental Health Makes Treatment Accessible and Compassionate

We don’t believe in one-size-fits-all. Our providers offer 30-minute appointments (twice the national average), take the time to listen, and personalize treatment plans. You don’t need a referral to get started. You can book a consultation online or call us at (720) 400-7025 to get started!

You Don’t Have to Wait for a Crisis: Why Early Intervention Matters

Treating mild symptoms early is easier and more effective than waiting for a crisis. You don’t need to hit rock bottom to get help. We’re here when you’re ready.

Learn More About Mental Health Recovery

• Marijuana and Mental Health

• Ketamine for Depression in Denver

• TMS for Treatment-Resistant Depression

FAQs

1. What are the most common symptoms of post-COVID depression?

2. Can COVID-19 cause permanent changes to my mental health?

3. How is post-COVID depression treated differently from other types of depression?

4. Does insurance cover alternative treatments like TMS or Ketamine?

5. How do I know if it’s time to seek professional help for post-COVID symptoms?